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KMID : 1041720170290010044
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Annals of Occupational and Environmental Medicine
2017 Volume.29 No. 1 p.44 ~ p.44
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Estimations of the lethal and exposure doses for representative methanol symptoms in humans
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Moon Chan-Seok
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Abstract
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Background: The aim of this review was to estimate the lethal and exposure doses of a representative symptom (blindness) of methanol exposure in humans by reviewing data from previous articles.
Methods: Available articles published from 1970 to 2016 that investigated the dose-response relationship for methanol exposure (i.e., the exposure concentration and the biological markers/clinical symptoms) were evaluated; the MEDLINE and RISS (Korean search engine) databases were searched. The available data from these articles were carefully selected to estimate the range and median of a lethal human dose. The regression equation and correlation coefficient (between the exposure level and urinary methanol concentration as a biological exposure marker) were assumed from the previous data.
Results: The lethal human dose of pure methanol was estimated at 15.8?474 g/person as a range and as 56.2 g/person as the median. The dose-response relationship between methanol vapor in ambient air and urinary methanol concentrations was thought to be correlated. An oral intake of 3.16?11.85 g/person of pure methanol could cause blindness. The lethal dose from respiratory intake was reported to be 4000?13,000 mg/l. The initial concentration of optic neuritis and blindness were shown to be 228.5 and 1103 mg/l, respectively, for a 12-h exposure.
Conclusion: The concentration of biological exposure indices and clinical symptoms for methanol exposure might have a dose-response relationship according to previous articles. Even a low dose of pure methanol through oral or respiratory exposure might be lethal or result in blindness as a clinical symptom.
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KEYWORD
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Methanol, Lethal dose, Blindness, Dose-response relation, Exposure, Review
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